Olanzapine & Fluoxetine tablets

Brand Name : OLANOL 5 F

Composition : Olanzapine & Fluoxetine tablets

Packing : 20x10

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Description :

 

Olanzapine & Fluoxetine tablets- The dual ingredient formulation is a prescription medication used in the treatment of bipolar depression and treatment resistant major depression in adults. Olanzapine is a typical antipsychotic that helps reduce mood swings, agitation and psychosis. Fluoxetine is a SSRI antidepressant which increases serotonin levels in the brain.

The combination of this medication is FDA approved. The medication works effectively to increase the extracellular levels of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain’s prefrontal cortex, which is critical for treating depressive symptoms. Fluoxetine is effective in maintaining remission for patients with treatment-resistant depression.

The medicine is manufactured and supplied by Lifegenix under the brand name Olanol 5F. Lifegenix is an ISO and WHO-GMP certified company that specializes in neuropsychiatry, cardiac, gastroenterological,and general medicines. The company also offers business opportunities such as PCD pharma franchise and third-party manufacturing services for business seekers.

Mechanism of Olanzapine & Fluoxetine tablets

Olanzapine- It blocks serotonin receptors and dopamine D2 receptors in the brain. It works to stabilize mood, decrease psychotic symptoms, and potentially improve negative symptoms of depression such as low energy and anhedonia.

Fluoxetine- It functions as a selective serotonin reuptake inhibitor (SSRI), which helps in inhibiting the reuptake pump on the neuronal membrane to increase serotonin levels in the synaptic cleft. 

The combined action of both components results in a more significant increase in the prefrontal cortex in the brain as compared to the drug alone. 

Benefits of Olanzapine & Fluoxetine tablets

• It is approved for patients who have not responded to two or more antidepressants. 
• This is effective at treating the depressive phase of bipolar disorder.
• It decreases agitation and helps patients think more clearly and positively.
• It helps in planning and completing daily activities, thereby leading to improved quality life of patients.

Side Effects of Olanzapine & Fluoxetine tablets

This medication is associated with certain side effects. Most of these are manageable and do not require discontinuation. Monitoring symptoms helps ensure safe continuation of the therapy. 

• Weight gain and increased appetite
• Drowsiness
• Sleepiness
• Constipation
• Headache
• Trouble concentrating

Precautions and safety measures for Olanzapine & Fluoxetine tablets

For best results, the medicine should be used with appropriate care and attention. Consulting a healthcare professional and following below instructions can help ensure a smooth and safe treatment. 

• Antidepressants increase the risks of suicidal thoughts and behaviors in children, adolescents and young adults.
• Keep monitoring for new behavior changes and symptoms.
• Avoid drinking alcohol as it increases dizziness and drowsiness which can lead to falls or injuries.
• The combination medication affects your concentration, hence avoid driving until you know how the medication affects you.
• Monitor regular weight, blood sugar, and blood lipids, especially for diabetes.
• The medication can affect the body’s ability to cool down. Avoid becoming dehydrated or overheated.
• If you are pregnant, use only if the benefit justifies the risk to the fetus, particularly in the third trimester.
• The tablets are not recommended for breastfeeding women.

Frequently Asked Questions (FAQs)

Q1- Why do Olanzapine & Fluoxetine tablets cause weight gain?

A- It can cause weight gain through Olanzapine’s high affinity for histamine H1 and serotonin 5-HT2C receptors which drastically increases appetite and cravings for carbohydrates.

Q2- How long does Olanzapine & Fluoxetine tablets take to start working?

A- The medication starts working within 1-2 weeks with therapeutic effects developing over 4-6 weeks.

Q3- What are the other medications that I should avoid while taking Olanzapine & Fluoxetine tablets?

A- Avoid taking MAO inhibitors, Thioridazine and Pimozide, Benzodiazepines and sedatives, and other NSAIDs and blood thinners.

Q4- What are the symptoms that I should inform my doctor immediately while consuming Olanzapine & Fluoxetine tablets?

A- High fever, confusion, irregular heartbeat, suicidal thoughts, chest pain, allergic reactions are symptoms that you should inform your doctor as soon as possible.

Q5- Will Olanzapine and Fluoxetine tablets stop mood swings?

A- Olanzapine with fluoxetine may help stabilize mood swings in some conditions, but effectiveness varies and medical guidance is essential.

Q6- Is Olanzapine and Fluoxetine tablets safe for long-term mental health treatment?

A- It is effective for long-term treatment of bipolar depression or resistant depression but carries significant risks that require consistent monitoring.