Esomeprazole Magnesium Trihydrate eq. to Esomeprazole 40 mg. (As enteric coated Pellets) Domperidone I.P. 30 mg. (As sustained release pellets) Excipients


Brand Name : ESOMAP DSR

Composition : Esomeprazole Magnesium Trihydrate eq. to Esomeprazole 40 mg. (As enteric coated Pellets) Domperidone I.P. 30 mg. (As sustained release pellets) Excipients

Packing : (10x 10)

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Description :

Domperidone + Esomeprazole is used in the treatment of gastroesophageal reflux disease (acid reflux) and functional dyspepsia.  In some people due to excess acid production in the stomach, the mucous layer gets eroded, which leads to health issues like GERD, acidity, peptic ulcers, and Zollinger-Ellison syndrome. Esomeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. The combined action of Domperidone + Esomeprazole provides relief from acidity-related problems. 

Take the medicine as per the described dosage and duration. Do not crush, chew or break the tablets. Swallow the whole tablet with water. The common side effects of this medicine are dry mouth, stomach pain, diarrhea, headache, and flatulence. Mostly the side effects get resolved over time and do not require any medical attention. Inform your doctor if you are allergic to Domperidone, Esomeprazole, or similar medicines. 

Medical Benefits of Domperidone + Esomeprazole

Domperidone is a prokinetic which targets the upper digestive tract and increases the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Esomeprazole is a proton pump inhibitor (PPI) that works by reducing the amount of acid in the stomach and providing relief from acid-related indigestion and heartburn. The medicine is used in the treatment of the following mentioned diseases: 

  • Gastroesophageal reflux disease (GERD)
  • Zollinger-Ellison syndrome
  • Stomach ulcers

Side Effects of Domperidone + Esomeprazole

There are mild to moderate side effects of Domperidone + Esomeprazole tablets that do not last for a long time. If your side effects persist or get severe with time, immediately contact your doctor. The side effects vary in all the users and depend on the physiological conditions and response to the therapy. The commonly experienced side effects of Domperidone + Esomeprazole tablets are mentioned following: 

  • Diarrhea
  • Flatulence
  • Headache
  • Nausea
  • Vomiting
  • Constipation
  • Fundic gland polyps
  • Abdominal pain

Drug Interaction 

Some drugs may interact with each other and cause ill health effects. The drugs can also interact with Domperidone + Esomeprazole tablets  It is advised to not take this medicine along with the drugs mentioned below:

  • anti-HIV (atazanavir, nelfinavir, saquinavir, ritonavir)
  • blood thinner (clopidogrel, warfarin)
  • anti-fungal (ketoconazole, itraconazole, voriconazole, fluconazole)
  • anti-cancer (erlotinib, toremifene, vandetanib, vincamine)
  • benzodiazepine (diazepam)
  • anti-convulsant (phenytoin)
  • anti-platelet (Cilostazol)
  • antacid (cisapride, dolasetron, prucalopride)
  • immunosuppressant (tacrolimus)
  • anti-TB (rifampicin)
  • antibiotics (Erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine)
  • anti-rheumatoid (methotrexate)
  • anti-depressant (citalopram, escitalopram)
  • cardiac glycoside (digoxin)
  • anti-malarial (halofantrine)
  • anti-psychotic (haloperidol, pimozide, sertindole)
  • anti-allergy (mequitazin, mizolastine)
  • anti-arrhythmic (amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol)
  • anti-hypertensives (diltiazem, verapamil)
  • St.John’s wort (herbal supplement used to treat depression)

Precautions and Warnings 

1. Avoid consuming alcohol with this medicine as it leads to increased drowsiness and increases the production of stomach acid. 

2. Do not take the tablets without a doctor’s consultation if you are pregnant or breastfeeding. 

3. The prolonged dosage of  Domperidone + Esomeprazole tablets may cause low magnesium levels, and vitamin B12 levels, which might increase the risk of bone fractures. 

4. Strictly adhere to the dosage and duration prescribed by the doctor and complete the full course of the medicine. 

5. Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.

.6 Keep the medicine out of reach of children and pets. Properly dispose of expired and discarded medicine. 

Frequently Asked Questions (FAQs) 

  1. What is the best time to take Domperidone + Esomeprazole Tablets?

It is best to take Domperidone+Esomeprazole before the first meal of the day or on an empty stomach.

  1. Can the use of Domperidone + Esomeprazole tables cause abnormal heartbeat?

Yes, the use of Domperidone+Esomeprazole increases the risk of irregular heartbeat (serious arrhythmias). This is a severe side effect but the chance that it may happen is very low. The risk is slightly higher in those who are more than 60 years of age.

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